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[Rioprostil 600 micrograms at night: marked inhibition of nocturnal intragastric acidity in man].

Authors
  • Dammann, H G
  • Rehner, M
  • Walter, T A
  • Müller, P
  • Simon, B
Type
Published Article
Journal
Zeitschrift für Gastroenterologie
Publication Date
May 01, 1986
Volume
24
Issue
5
Pages
245–249
Identifiers
PMID: 3088858
Source
Medline
License
Unknown

Abstract

Antisecretory doses of prostaglandin analogues of the E1 and E2 series have been shown to promote peptic ulcer healing. In this double blind randomized cross-over study we investigated the effect of oral Rioprostil 300 micrograms b.i.d., 600 micrograms hs and placebo on 24 h intragastric H+ activity in 9 healthy male volunteers (age 20-37 years). 5-10 ml of gastric contents were aspirated hourly via a nasogastric tube. The pH of the samples was determined using a glass electrode . The results were expressed in terms of H+ activity (mmol/l). Night acidity (AUC/h, 2400-0800) is decreased by rioprostil in a dose related fashion (300 micrograms: 52%, 600 micrograms: 74%). The effect on day-time (0900-1800) H+ activity is much less. Rioprostil 300 micrograms given at breakfast reduce day-time acidity by 33%. Our results suggest that 600 micrograms Rioprostil in a single bedtime dose is effective in peptic ulcer treatment.

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