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Is rigorous retrospective harmonization possible? Application of the DataSHaPER approach across 53 large studies.

Authors
  • Fortier, Isabel
  • Doiron, Dany
  • Little, Julian
  • Ferretti, Vincent
  • L'Heureux, François
  • Stolk, Ronald P
  • Knoppers, Bartha M
  • Hudson, Thomas J
  • Burton, Paul R
Type
Published Article
Journal
International Journal of Epidemiology
Publisher
Oxford University Press
Publication Date
Oct 01, 2011
Volume
40
Issue
5
Pages
1314–1328
Identifiers
DOI: 10.1093/ije/dyr106
PMID: 21804097
Source
Medline
License
Unknown

Abstract

The current article shows that the DataSHaPER provides an effective and flexible approach for the retrospective harmonization of information across studies. To implement data synthesis, some additional scientific, ethico-legal and technical considerations must be addressed. The success of the DataSHaPER as a harmonization approach will depend on its continuing development and on the rigour and extent of its use. The DataSHaPER has the potential to take us closer to a truly collaborative epidemiology and offers the promise of enhanced research potential generated through synthesized databases.

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