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Rifabutin Use in Staphylococcus Biofilm Infections: A Case Series

Authors
  • Doub, James B.
  • Heil, Emily L.
  • Ntem-Mensah, Afua
  • Neeley, Renaldo
  • Ching, Patrick R.
Type
Published Article
Journal
Antibiotics
Publisher
MDPI AG
Publication Date
Jun 13, 2020
Volume
9
Issue
6
Identifiers
DOI: 10.3390/antibiotics9060326
PMID: 32545793
PMCID: PMC7345564
Source
PubMed Central
Keywords
License
Green

Abstract

This is a case series of 10 patients who had staphylococcal biofilm infections that were treated with adjuvant rifabutin therapy instead of rifampin therapy. In these cases, rifampin was contraindicated secondary to drug–drug interactions with the patients’ chronic medications. Rifabutin therapy was well tolerated with no side effects. As well, no patients had recurrence of their staphylococcal infections. This case series shows that rifabutin can be a beneficial adjuvant therapy in Staphylococcus biofilm infections when drug–drug interactions limit the use of rifampin.

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