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A RIDDle solved: why an intact IRE1α/XBP-1 signaling relay is key for humoral immune responses.

Authors
  • van Anken, Eelco1
  • Orsi, Andrea
  • Sitia, Roberto
  • 1 San Raffaele Scientific Institute & Università Vita-Salute San Raffaele, Milan, Italy. , (Italy)
Type
Published Article
Journal
European Journal of Immunology
Publisher
Wiley (John Wiley & Sons)
Publication Date
Mar 01, 2014
Volume
44
Issue
3
Pages
641–645
Identifiers
DOI: 10.1002/eji.201444461
PMID: 24497153
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

As they commit to plasma cell differentiation, B lymphocytes must swiftly gear up to produce and secrete huge amounts of antibodies. To develop their secretory capacity, B cells exploit a signaling pathway that is employed by all eukaryotic cells in response to endoplasmic reticulum stress. An article by Benhamron et al. in this issue of the European Journal of Immunology, [Eur. J. Immunol. 2014. 44: 867-876] sheds new light on why an intact IRE1/XBP-1 signaling relay is central to orchestrate the full-blown expansion of the secretory machinery needed for massive antibody production. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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