Affordable Access

Access to the full text

Ribosome recycling in mRNA translation, quality control, and homeostasis

Authors
  • Nürenberg-Goloub, Elina1
  • Tampé, Robert1
  • 1 Institute of Biochemistry, Biocenter, Goethe University Frankfurt, Max-von-Laue-Str. 9 , (Germany)
Type
Published Article
Journal
Biological Chemistry
Publisher
Walter de Gruyter GmbH
Publication Date
Nov 14, 2019
Volume
401
Issue
1
Pages
47–61
Identifiers
DOI: 10.1515/hsz-2019-0279
Source
De Gruyter
Keywords
License
Yellow

Abstract

Protein biosynthesis is a conserved process, essential for life. Ongoing research for four decades has revealed the structural basis and mechanistic details of most protein biosynthesis steps. Numerous pathways and their regulation have recently been added to the translation system describing protein quality control and messenger ribonucleic acid (mRNA) surveillance, ribosome-associated protein folding and post-translational modification as well as human disorders associated with mRNA and ribosome homeostasis. Thus, translation constitutes a key regulatory process placing the ribosome as a central hub at the crossover of numerous cellular pathways. Here, we describe the role of ribosome recycling by ATP-binding cassette sub-family E member 1 (ABCE1) as a crucial regulatory step controlling the biogenesis of functional proteins and the degradation of aberrant nascent chains in quality control processes.

Report this publication

Statistics

Seen <100 times