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The autoimmune disease-associated transcription factors EOMES and TBX21 are dysregulated in multiple sclerosis and define a molecular subtype of disease

Authors
  • Parnell, Grant P.
  • Gatt, Prudence N.
  • Krupa, Malgorzata
  • Nickles, Dorothee
  • McKay, Fiona C.
  • Schibeci, Stephen D.
  • Batten, Marcel
  • Baranzini, Sergio
  • Henderson, Andrew
  • Barnett, Michael
  • Slee, Mark
  • Vucic, Steve
  • Stewart, Graeme J.
  • Booth, David R.1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 9, 11
  • 1 Institute for Immunology and Allergy Research
  • 2 Westmead Millennium Institute University of Sydney
  • 3 School of Medicine
  • 4 Flinders University of South Australia
  • 5 Department of Neurology
  • 6 University of California at San Francisco
  • 7 Garvan Institute of Medical Research
  • 8 Brain and Mind Research Institute
  • 9 University of Sydney
  • 10 Westmead Clinical School
  • 11 Westmead Hospital
Type
Published Article
Journal
Clinical Immunology
Publisher
Elsevier BV
Publication Date
Jan 01, 2014
Accepted Date
Jan 07, 2014
Volume
151
Issue
1
Pages
16–24
Identifiers
DOI: 10.1016/j.clim.2014.01.003
Source
Elsevier
Keywords
License
Unknown

Abstract

•Transcription factors are over-represented among MS risk factor genes.•EOMES, TBX21, and ZMIZ1 are underexpressed in MS in 3 independent cohorts.•Expression of EOMES, TBX21, RUNX3, TOX and CCL5 is positively correlated in blood.•Their expression is stable over time for individuals.•Expression of these genes in blood defines a molecular phenotype of MS.

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