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Riboflavin metabolism in the hypothyroid newborn.

Authors
  • Cimino, J A
  • Noto, R A
  • Fusco, C L
  • Cooperman, J M
Type
Published Article
Journal
The American journal of clinical nutrition
Publication Date
Mar 01, 1988
Volume
47
Issue
3
Pages
481–483
Identifiers
PMID: 3348160
Source
Medline
License
Unknown

Abstract

In the hypothyroid rat the flavin adenine dinucleotide (FAD) content of the liver is similar to that observed in rats maintained on a riboflavin-deficient diet. Thyroxine regulates the enzyme flavin kinase. Human adults with hypothyroidism have levels of erythrocyte glutathione reductase (EGR), an FAD-containing enzyme, in the range indicative of riboflavin deficiency, which can be corrected with thyroxine therapy. In the present study six newborns with severe congenital hypothyroidism because of athyrosis, ectopic thyroidism, or congenital hypothyroidism with Down's syndrome had normal levels of EGR, and treatment with thyroxine had no effect on these levels.

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