Affordable Access

deepdyve-link
Publisher Website

Rhodium(III)- and iridium(III)-catalyzed C7 alkylation of indolines with diazo compounds.

Authors
  • Ai, Wen
  • Yang, Xueyan
  • Wu, Yunxiang
  • Wang, Xuan
  • Li, Yuanchao
  • Yang, Yaxi
  • Zhou, Bing
Type
Published Article
Journal
Chemistry - A European Journal
Publisher
Wiley (John Wiley & Sons)
Publication Date
Dec 22, 2014
Volume
20
Issue
52
Pages
17653–17657
Identifiers
DOI: 10.1002/chem.201405077
PMID: 25359110
Source
Medline
Keywords
License
Unknown

Abstract

A Rh(III)-catalyzed procedure for the C7-selective C-H alkylation of various indolines with α-diazo compounds at room temperature is reported. The advantages of this process are: 1) simple, mild, and pH-neutral reaction conditions, 2) broad substrate scope, 3) complete regioselectivity, 4) no need for an external oxidant, and 5) N2 as the sole byproduct. Furthermore, alkylation and bis-alkylation of carbazoles at the C1 and C8 positions have also been developed. More significantly, for the first time, a successful Ir(III)-catalyzed intermolecular insertion of arene C-H bonds into α-diazo compounds is reported.

Report this publication

Statistics

Seen <100 times