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Rhodium(iii)-catalyzed regio- and stereoselective benzylic α-fluoroalkenylation with gem-difluorostyrenes.

Authors
  • Kong, Lingheng1
  • Liu, Bingxian
  • Zhou, Xukai
  • Wang, Fen
  • Li, Xingwei
Type
Published Article
Journal
Chemical Communications
Publisher
The Royal Society of Chemistry
Publication Date
Sep 13, 2017
Volume
53
Issue
74
Pages
10326–10329
Identifiers
DOI: 10.1039/c7cc06048c
PMID: 28872180
Source
Medline
License
Unknown

Abstract

Rhodium(iii)-catalyzed mild benzylic α-fluoroalkenylation of 8-methylquinolines with gem-difluorostyrenes has been developed. This reaction occurred via C-H activation and C-F cleavage and is applicable to a wide range of substrates, leading to the synthesis of Z-alkenyl fluorides under mild and redox-neutral conditions with high regio- and stereoselectivity.

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