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Rho signaling and tight junction functions.

Authors
  • Terry, Steve
  • Nie, Mei
  • Matter, Karl
  • Balda, Maria S
Type
Published Article
Journal
Physiology (Bethesda, Md.)
Publication Date
Feb 01, 2010
Volume
25
Issue
1
Pages
16–26
Identifiers
DOI: 10.1152/physiol.00034.2009
PMID: 20134025
Source
Medline
License
Unknown

Abstract

Tight junctions are heteromeric protein complexes that act as signaling centers by mediating the bidirectional transmission of information between the environment and the cell interior to control paracellular permeability and differentiation. Insight into tight junction-associated signaling mechanisms is of fundamental importance for our understanding of the physiology of epithelia and endothelia in health and disease.

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