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Rhesus immune responses to SIV Gag expressed by recombinant BCG vectors are independent from pre-existing mycobacterial immunity.

Authors
  • Korioth-Schmitz, Birgit1
  • Perley, Casey C2
  • Sixsmith, Jaimie D1
  • Click, Eva M2
  • Lee, Sunhee2
  • Letvin, Norman L1
  • Frothingham, Richard3
  • 1 Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, United States. , (Israel)
  • 2 Duke University School of Medicine, Durham, NC 27710, United States. , (United States)
  • 3 Duke University School of Medicine, Durham, NC 27710, United States. Electronic address: [email protected] , (United States)
Type
Published Article
Journal
Vaccine
Publication Date
Oct 13, 2015
Volume
33
Issue
42
Pages
5715–5722
Identifiers
DOI: 10.1016/j.vaccine.2015.07.010
PMID: 26192357
Source
Medline
Keywords
License
Unknown

Abstract

Rhesus immune responses to SIV Gag expressed by rBCG vectors were independent from pre-existing anti-mycobacterial immunity. Rhesus macaques may serve as a surrogate for investigations of pre-existing anti-mycobacterial immunity in humans.

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