Affordable Access

RGS18 acts as a negative regulator of osteoclastogenesis by modulating the acid-sensing OGR1/NFAT signaling pathway.

Authors
  • Iwai, Kaori
  • Koike, Masato
  • Ohshima, Shiro
  • Miyatake, Kunio
  • Uchiyama, Yasuo
  • Saeki, Yukihiko
  • Ishii, Masaru
Type
Published Article
Journal
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Publication Date
Oct 01, 2007
Volume
22
Issue
10
Pages
1612–1620
Identifiers
PMID: 17576169
Source
Medline
License
Unknown

Abstract

RGS18 acts as a negative regulator of the acidosis-induced osteoclastogenic OGR1/NFAT signaling pathway, and RANKL stimulates osteoclastogenesis by inhibiting expression of RGS18. Therefore, the results suggest a novel control mechanism of osteoclastogenesis by RGS proteins.

Report this publication

Statistics

Seen <100 times