Affordable Access

deepdyve-link
Publisher Website

The reward value of sucrose in leptin-deficient obese mice

Authors
  • Domingos, Ana I.
  • Vaynshteyn, Jake
  • Sordillo, Aylesse
  • Friedman, Jeffrey M.1, 2, 3, 2, 4, 5
  • 1 Laboratory of Molecular Genetics
  • 2 Rockefeller University
  • 3 Howard Hughes Medical Institute
  • 4 Albert Einstein College of Medicine
  • 5 Rose F. Kennedy Center
Type
Published Article
Journal
Molecular Metabolism
Publisher
Elsevier BV
Publication Date
Jan 01, 2013
Accepted Date
Oct 30, 2013
Volume
3
Issue
1
Pages
73–80
Identifiers
DOI: 10.1016/j.molmet.2013.10.007
Source
Elsevier
Keywords
License
Unknown

Abstract

Leptin-deficient patients report higher “liking” ratings for food, and leptin replacement therapy normalizes these ratings even before weight loss is achieved. Since animals cannot report their ratings, we studied the relationship between leptin and food reward in leptin-deficient ob/ob mice using a optogenetic assay that quantifies the reward value of sucrose. In this assay, mice chose between one sipper dispensing the artificial sweetener sucralose coupled to optogenetic activation of dopaminergic (DA) neurons, and another sipper dispensing sucrose. We found that the reward value of sucrose was high under a state of leptin deficiency, as well as at a dose of leptin that does not suppress food intake (12.5ng/h). Treatment with higher doses of leptin decreased the reward value of sucrose before weight loss was achieved (100ng/h), as seen in leptin-deficient patients. These results phenocopy in mice the behavior of leptin-deficient patients.

Report this publication

Statistics

Seen <100 times