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Revisiting the Notion of Deleterious Sweeps.

Authors
  • Johri, Parul1
  • Charlesworth, Brian2
  • Howell, Emma K1
  • Lynch, Michael1, 3
  • Jensen, Jeffrey D1
  • 1 School of Life Sciences, Arizona State University, Tempe, AZ 85287, United States. , (United States)
  • 2 Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, EH9 3FL, United Kingdom. , (United Kingdom)
  • 3 Center for Mechanisms of Evolution, The Biodesign Institute, Arizona State University, Tempe, AZ 85287, United States. , (United States)
Type
Published Article
Journal
Genetics
Publisher
The Genetics Society of America
Publication Date
Jun 14, 2021
Identifiers
DOI: 10.1093/genetics/iyab094
PMID: 34125884
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

It has previously been shown that, conditional on its fixation, the time to fixation of a semi-dominant deleterious autosomal mutation in a randomly mating population is the same as that of an advantageous mutation. This result implies that deleterious mutations could generate selective sweep-like effects. Although their fixation probabilities greatly differ, the much larger input of deleterious relative to beneficial mutations suggests that this phenomenon could be important. We here examine how the fixation of mildly deleterious mutations affects levels and patterns of polymorphism at linked sites - both in the presence and absence of interference amongst deleterious mutations - and how this class of sites may contribute to divergence between-populations and species. We find that, while deleterious fixations are unlikely to represent a significant proportion of outliers in polymorphism-based genomic scans within populations, minor shifts in the frequencies of deleterious mutations can influence the proportions of private variants and the value of FST after a recent population split. As sites subject to deleterious mutations are necessarily found in functional genomic regions, interpretations in terms of recurrent positive selection may require reconsideration. © The Author(s) 2021. Published by Oxford University Press on behalf of the Genetics Society of America. All rights reserved. For permissions, please email: [email protected]

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