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A revisiting of "the hallmarks of aging" in domestic dogs: current status of the literature.

Authors
  • Jiménez, Ana Gabriela1
  • 1 Department of Biology, Colgate University, 13 Oak Dr, Hamilton, NY, 133546, USA. [email protected].
Type
Published Article
Journal
GeroScience
Publication Date
Feb 01, 2024
Volume
46
Issue
1
Pages
241–255
Identifiers
DOI: 10.1007/s11357-023-00911-5
PMID: 37594598
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

A progressive decline in biological function and fitness is, generally, how aging is defined. However, in 2013, a description on the "hallmarks of aging" in mammals was published, and within it, it described biological processes that are known to alter the aging phenotype. These include genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, deregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, altered intercellular communication (inflammation), and changes within the microbiome. This mini-review provides a detailed account of the progress on each of these hallmarks of aging in the domestic dog within the last 5 years. Additionally, when there are gaps in the literature between other mammalian species and dogs, I highlight the aging biomarkers that may be missing for dogs as aging models. I also argue for the importance of dog aging studies to include several breeds of dogs at differing ages and for age corrections for breeds with differing mean lifespans throughout. © 2023. The Author(s), under exclusive licence to American Aging Association.

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