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Revisiting the bromination of C-H bonds with molecular bromine by using a photo-microflow system.

Authors
  • Manabe, Yoshiyuki
  • Kitawaki, Yuriko
  • Nagasaki, Masahiro
  • Fukase, Koichi
  • Matsubara, Hiroshi
  • Hino, Yoshiko
  • Fukuyama, Takahide
  • Ryu, Ilhyong
Type
Published Article
Journal
Chemistry - A European Journal
Publisher
Wiley (John Wiley & Sons)
Publication Date
Sep 26, 2014
Volume
20
Issue
40
Pages
12750–12753
Identifiers
DOI: 10.1002/chem.201402303
PMID: 25170976
Source
Medline
Keywords
License
Unknown

Abstract

The photobromination of C-H bonds by using molecular bromine was reinvestigated under microfluidic conditions. The continuous-flow method suppressed the production of dibrominated compounds and effectively produced the desired monobrominated products with high selectivity. Rapid bromination of benzylic substrates containing a photoaffinity azide group was achieved without any decomposition.

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