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Review of the Y chromosome and hypertension.

Authors
  • Ely, D
  • Turner, M
  • Milsted, A
Type
Published Article
Journal
Brazilian Journal of Medical and Biological Research
Publisher
SciELO
Publication Date
Jun 01, 2000
Volume
33
Issue
6
Pages
679–691
Identifiers
PMID: 10829096
Source
Medline
License
Unknown

Abstract

The Y chromosome from spontaneously hypertensive rats (SHR) has a locus that raises blood pressure 20-25 mmHg. Associated with the SHR Y chromosome effect is a 4-week earlier pubertal rise of testosterone and dependence upon the androgen receptor for the full blood pressure effect. Several indices of enhanced sympathetic nervous system (SNS) activity are also associated with the SHR Y chromosome. Blockade of SNS outflow reduced the blood pressure effect. Salt sensitivity was increased by the Y chromosome as was salt appetite which was SNS dependent. A strong correlation (r = 0. 57, P<0.001) was demonstrable between plasma testosterone and angiotensin II. Coronary collagen increased with blood pressure and the presence of the SHR Y chromosome. A promising candidate gene for the Y effect is the Sry locus (testis determining factor), a transcription factor which may also have other functions.

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