Affordable Access

deepdyve-link
Publisher Website

Review: the ubiquitin-proteasome system: contributions to cell death or survival in neurodegeneration.

Authors
  • Rogers, N
  • Paine, S
  • Bedford, L
  • Layfield, R
Type
Published Article
Journal
Neuropathology and applied neurobiology
Publication Date
Apr 01, 2010
Volume
36
Issue
2
Pages
113–124
Identifiers
DOI: 10.1111/j.1365-2990.2010.01063.x
PMID: 20202119
Source
Medline
License
Unknown

Abstract

The significance of the accumulation of ubiquitin-positive intraneuronal inclusions in the brains of those affected with different neurodegenerative diseases is currently unclear. While one interpretation is that the disease mechanism(s) involves dysfunction of an ubiquitin-mediated process, such as the ubiquitin-proteasome system, the inclusions are also found in surviving neurones, suggesting a possible neuroprotective role. Here we review recent evidence in support of these seemingly opposing notions gleaned from cell and animal models as well as investigations of patient samples, with particular emphasis on studies relevant to Parkinson's disease.

Report this publication

Statistics

Seen <100 times