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Review series: The cell biology of renal filtration.

Authors
  • Scott, Rizaldy P
  • Quaggin, Susan E
Type
Published Article
Journal
Journal of Cell Biology
Publisher
Rockefeller University Press
Publication Date
Apr 27, 2015
Volume
209
Issue
2
Pages
199–210
Identifiers
DOI: 10.1083/jcb.201410017
PMID: 25918223
Source
Medline
License
Unknown

Abstract

The function of the kidney, filtering blood and concentrating metabolic waste into urine, takes place in an intricate and functionally elegant structure called the renal glomerulus. Normal glomerular function retains circulating cells and valuable macromolecular components of plasma in blood, resulting in urine with just trace amounts of proteins. Endothelial cells of glomerular capillaries, the podocytes wrapped around them, and the fused extracellular matrix these cells form altogether comprise the glomerular filtration barrier, a dynamic and highly selective filter that sieves on the basis of molecular size and electrical charge. Current understanding of the structural organization and the cellular and molecular basis of renal filtration draws from studies of human glomerular diseases and animal models of glomerular dysfunction.

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