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A review on response of immune system in spinal cord injury and therapeutic agents useful in treatment.

Authors
  • Kasinathan, Narayanan
  • Vanathi, Meenashi B
  • Subrahmanyam, Volety M
  • Rao, Josyula V
Type
Published Article
Journal
Current Pharmaceutical Biotechnology
Publisher
Bentham Science
Publication Date
Jan 01, 2015
Volume
16
Issue
1
Pages
26–34
Identifiers
PMID: 25374028
Source
Medline
License
Unknown

Abstract

Every year more than 12,000 people in US alone suffer from spinal cord injury. However, complete recovery of physical function is difficult due to multiple factors involved in disease progression. Currently available therapeutic regimens do not address all the factors concerned with the disease progression. The present review focuses mainly on the role of immune cells in progression of spinal cord injury and the drugs that target these immune cells. Literature search shows that inflammatory reactions and subsequent reactions that follow direct injury to spinal cord are sometimes responsible for the severity of the disease. Therefore, for design of proper treatment regimen a deep understanding in this area is required. Understanding the pathophysiology will help in creating delivery system that can target multiple factors involved in progression of spinal cord injury. A combination of various treatment strategies is required to reduce the disability in patients with spinal cord injury.

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