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A review found inadequate reporting of case-control studies of risk factors for pancreatic cancer.

Authors
  • MacCarthy, Angela1
  • Dhiman, Paula2
  • Kirtley, Shona3
  • Logullo, Patricia2
  • Copsey, Bethan3
  • Collins, Gary S2
  • 1 Centre for Statistics in Medicine, University of Oxford, Botnar Research Centre, Windmill Road, Oxford OX3 7LD, UK. Electronic address: [email protected]
  • 2 Centre for Statistics in Medicine, University of Oxford, Botnar Research Centre, Windmill Road, Oxford OX3 7LD, UK; NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford OX3 9DU, UK.
  • 3 Centre for Statistics in Medicine, University of Oxford, Botnar Research Centre, Windmill Road, Oxford OX3 7LD, UK.
Type
Published Article
Journal
Journal of clinical epidemiology
Publication Date
May 01, 2021
Volume
133
Pages
32–42
Identifiers
DOI: 10.1016/j.jclinepi.2020.12.020
PMID: 33359318
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Case-control studies are often used to identify the risk factors for pancreatic cancer. The objective of this study was to evaluate the reporting of case-control studies of the risk factors for pancreatic cancer using the Strengthening The Reporting of OBservational Studies in Epidemiology (STROBE) for case-control studies checklist. We conducted a comprehensive literature search of the MEDLINE and EMBASE databases to identify reports of case-control studies published between 2016 and 2018. We scored article reporting using a reporting adherence form developed from the STROBE checklist for case-control studies, consisting of 14 STROBE items related to the title, abstract, methods, and results sections. We included reports of 47 case-control studies investigating a variety of risk factors, such as medical conditions and lifestyle factors. Reporting was inconsistent and inadequate. Efforts to address bias and how the study size was arrived at were particularly poorly described. Study cases were described in more detail than study controls. Reporting of case-control studies remains inadequate more than 10 years after the STROBE reporting guideline was published. Our findings suggest that authors do not understand the extent to which study methods and findings should be reported to enable studies to be fully understood, and their methods reproduced. Copyright © 2021 The Author(s). Published by Elsevier Inc. All rights reserved.

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