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Review of experimental studies on nitrosourea derivatives in Japan.

Authors
Type
Published Article
Journal
Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer
Publication Date
Volume
70
Pages
107–117
Identifiers
PMID: 7355242
Source
Medline
License
Unknown

Abstract

Four antitumor nitrosourea derivatives under development in Japan are described. Among these, GANU and MCNU, having very similar structures to chlorozotocin, are water-soluble compounds, and CDL-7 and EBNU are rather insoluble in water. The latter two are before clinical trials, and like other nitrosourea derivatives, have a marked antitumor activity in mouse leukemia L1210. Though GANU and MCNU are in the stage of clinical studies, it seems premature to draw conclusions about them. Antitumor activity and pharmacologic studies on four nitrosourea compounds under development in Japan are reviewed. These compounds are: 1-(2-chloroethyl)-3-(beta-D-glucopyranosyl)-1-nitrosourea (GANU), 1-(2-chloroethyl)-3-(methyl-alpha-D-glucopyranos-6-yl)-1-nitrosourea (MCNU), DL-1(2-chloroethyl)-3-(hexahydro-2-oxo-azepin-3-yl)-1-nitrosourea (CDL-7), and 1,1'-ethylene-bis(1-nitrosourea) (EBNU).

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