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A review of basic concepts in comprehensive two-dimensional gas chromatography.

Authors
Type
Published Article
Journal
Journal of chromatographic science
Publication Date
Volume
40
Issue
5
Pages
276–291
Identifiers
PMID: 12049157
Source
Medline
License
Unknown

Abstract

The technique of comprehensive two-dimensional gas chromatography (GCxGC) is reviewed. A description of technical aspects of the method illustrates how the GCxGC result is achieved through the use of dual-coupled columns and the modulation of capillary chromatographic peaks. This review presents an expanded section dealing with the relationship between the modulation phase and frequency and the resulting peak pulse profiles. Experimental results that support the appreciation and understanding of the effects that pulsing has on a chromatographic peak are provided. The main goals of GCxGC analysis are discussed with respect to analytical sensitivity and peak capacity arising from zone compression effects and fast analysis on the second column. A typical application of GCxGC is presented, along with a consideration of implementation of the GCxGC method.

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