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Review article: glucagon-like peptide 2--current applications and future directions.

Authors
  • Wallis, K
  • Walters, J R F
  • Forbes, A
Type
Published Article
Journal
Alimentary pharmacology & therapeutics
Publication Date
Feb 15, 2007
Volume
25
Issue
4
Pages
365–372
Identifiers
PMID: 17217448
Source
Medline
License
Unknown

Abstract

In the treatment of short bowel syndrome, GLP-2 has been shown to be highly effective in improving fluid absorption. In Crohn's disease, GLP-2 is superior to placebo in the induction of remission. Early data also suggest that the effects of GLP-2 on bone metabolism can provide a new treatment approach for patients with osteoporosis. In the future, the positive effects of GLP-2 on intestinal barrier function, splanchnic perfusion and mucosal healing could be utilized to expand its therapeutic application to other causes of intestinal injury. However, important safety aspects need to be considered when using this potent growth-promoting agent for a long term.

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