Affordable Access

deepdyve-link
Publisher Website

A Review about Regulatory Status and Recent Patents of Pharmaceutical Co-Crystals.

Authors
  • Kumar, Arun1
  • Kumar, Sandeep1
  • Nanda, Arun1
  • 1 Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak-124001, India. , (India)
Type
Published Article
Journal
Advanced pharmaceutical bulletin
Publication Date
Aug 01, 2018
Volume
8
Issue
3
Pages
355–363
Identifiers
DOI: 10.15171/apb.2018.042
PMID: 30276131
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Pharmaceutical Co-crystals are not new, they have gained much attention since the last decade among scientists and pharmaceutical industry. Pharmaceutical co-crystals are multicomponent systems composed of two or more molecules and held together by non-covalent interactions. The development of pharmaceutical co-crystals, a new solid crystalline form, offer superior physico-chemical properties (such as melting point, stability, solubility, permeability, bioavailability, taste masking, etc.) without altering the pharmacological properties. Recently, with the upsurge in the growth of Pharmaceutical co-crystals, the major concern is over the regulatory status of co-crystals. With the new guidelines from United States Food and Drug Administration (USFDA) and European Medicines Agency (EMA), the status has become even more complicated due to significantly different opinions. This review highlights whether co-crystals fulfil the requirements for the grant of a patent or not and how cocrystals are going to affect the present scenario of pharmaceuticals.

Report this publication

Statistics

Seen <100 times