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Reversion of 'early worsening' of diabetic retinopathy by deliberate restoration of poor metabolic control.

Authors
  • Chantelau, E
  • Meyer-Schwickerath, R
Type
Published Article
Journal
Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde
Publication Date
Jan 01, 2003
Volume
217
Issue
5
Pages
373–377
Identifiers
PMID: 12913330
Source
Medline
License
Unknown

Abstract

Acutely lowering long-standing severe hyperglycaemia can trigger progression ('early worsening') of diabetic retinopathy, most likely by up-regulation of the circulating insulin-like growth factor 1 (IGF-1). This condition, also called 'florid retinopathy', rarely responds to standard laser coagulation treatment. In this retrospective report, 2 young patients with type 2 diabetes are described, in whom deliberate restoration of poor diabetes control reduced the serum IGF-1 levels and improved 'early worsened' diabetic retinopathy.

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