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Reversible and oxidative inactivation of endogenous survival factors after removal of exogenous survival factors.

Authors
  • Engelmann, I
  • Bauer, G
Type
Published Article
Journal
International journal of oncology
Publication Date
Jul 01, 2000
Volume
17
Issue
1
Pages
97–102
Identifiers
PMID: 10853024
Source
Medline
License
Unknown

Abstract

Serum contains exogenous survival factors for fibroblasts. Removal of these exogenous factors causes inactivation of endogenous survival factors, subsequent release of a constitutively expressed apoptosis machinery from negative control and apoptosis. Inactivation of endogenous survival factors after serum withdrawal is mediated by reactive oxygen species and can be rapidly reversed through re-addition of serum. Oxidative inactivation of endogenous survival factors after depletion of exogenous survival factors as well as the process of reversion to the active state do not require protein synthesis, indicating the existence of a constitutively expressed regulatory system that controls the interaction of exogenous and endogenous survival factors.

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