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A reversible near-infrared fluorescence probe for reactive oxygen species based on Te-rhodamine.

Authors
  • Koide, Yuichiro
  • Kawaguchi, Mitsuyasu
  • Urano, Yasuteru
  • Hanaoka, Kenjiro
  • Komatsu, Toru
  • Abo, Masahiro
  • Terai, Takuya
  • Nagano, Tetsuo
Type
Published Article
Journal
Chemical Communications
Publisher
The Royal Society of Chemistry
Publication Date
Mar 25, 2012
Volume
48
Issue
25
Pages
3091–3093
Identifiers
DOI: 10.1039/c2cc18011a
PMID: 22344329
Source
Medline
License
Unknown

Abstract

We have designed and synthesized a reversible near-infrared (NIR) fluorescence probe, 2-Me TeR, for reactive oxygen species (ROS), utilizing the redox properties of the tellurium (Te) atom. 2-Me TeR is oxidized to fluorescent 2-Me TeOR by various ROS, while the generated 2-Me TeOR is quickly reduced in the presence of glutathione to regenerate 2-Me TeR. This redox-induced reversible NIR-fluorescence response of 2-Me TeR allowed us to detect the endogenous production of ROS and subsequent homeostatic recovery of the intracellular reductive environment in hydrogen peroxide-stimulated HL-60 cells. This probe is expected to be useful for monitoring the dynamics of ROS production continuously in vivo.

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