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Reversible effects of olfactory nerve section on behavior and biochemistry in mice.

Authors
Type
Published Article
Journal
Brain Research Bulletin
0361-9230
Publisher
Elsevier
Publication Date
Volume
4
Issue
1
Pages
17–22
Identifiers
PMID: 89004
Source
Medline
License
Unknown

Abstract

Coincident with the sectioning of the primary olfactory nerves in mice there is a dramatic loss of both olfactory-mediated behavior and the ability of the primary olfactory neurons to synthesize and transport the neuron specific marker, carnosine. These deficiencies are only temporary, and the ability of food deprived mice to locate buried food pellets returns within 21 days after olfactory nerve section. The ability of the primary olfactory neurons to synthesize and transport carnosine appears to increase between 8 days and 45 days after surgery. These data support the notion of behaviorally significant functional regeneration of olfactory neurons.

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