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Reversible acute tubular necrosis following severe acute renal rejection.

Authors
  • Schmidt, P
  • Pinggera, W F
  • Zazgornik, J
  • Stummvoll, H K
  • Wolf, A
  • Kopsa, H
  • Pils, P
Type
Published Article
Journal
International urology and nephrology
Publication Date
Jan 01, 1979
Volume
11
Issue
1
Pages
61–66
Identifiers
PMID: 381234
Source
Medline
License
Unknown

Abstract

The clinical observation of 6 out of 250 renal transplant patients showed that acute renal rejection may lead to reversible acute tubular necrosis (ATN) necessitating intermittent haemodialysis treatment. Despite missing early response to high-dose (methyl-) prednisolone therapy (during a mean period of 4.7 days) all 6 patients developed spontaneous diuresis 14.5 days on average after onset of rejection while on maintenance immunosuppressive therapy. From the clinical course the conclusion was drawn that in severe cases of renal rejection with arteriographic and histological findings consistent with acute tubular necrosis, prolonged therapy with high doses of (methyl-) prednisolone is not desirable, since after reversal of immunological rejection the onset of spontaneous diuresis will be determined mainly by the duration of the healing and recovery phase of acute tubular necrosis.

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