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Reversed-phase TLC study of some long chain arylpiperazine of imidazolidine-2,4-dione and imidazo[2,1-f]purine-2,4-dione derivatives.

Authors
  • Zagórska, Agnieszka
  • Czopek, Anna
  • Pełka, Karolina
  • Stanisz-Wallis, Krystyna
  • Pawłowski, Maciej
Type
Published Article
Journal
Acta poloniae pharmaceutica
Publication Date
Jan 01, 2014
Volume
71
Issue
3
Pages
379–383
Identifiers
PMID: 25265816
Source
Medline
License
Unknown

Abstract

The chromatographic parameters of arylpiperazinylpropyl derivatives of imidazolidine-2,4-dione and imidazo[2,1-f]purine-2,4-dione were investigated using reversed-phase thin layer chromatography method. The results revealed that R(M0) of investigated compounds depended on substituent in arylpiperazinyl fragment as well as on a nature of (cycloalkyl)aromatic ring at 5 position of imidazolidine-2,4-dione and at 7 position of imidazo[2,1-f]theophylline. The R(M0) parameters were compared with computationally calculated partition coefficients values by principal component analysis (PCA). To verify the influence of lipophilic parameter of investigated compounds on their biological activity the statistical analysis of Mann-Whitney was performed.

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