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Reversal of temperature-induced conformational changes in the amyloid-beta peptide, Abeta40, by the beta-sheet breaker peptides 16-23 and 17-24.

Authors
  • Hatip, Funda F Bölükbaşi
  • Suenaga, Midori
  • Yamada, Tatsuo
  • Matsunaga, Yoichi
Type
Published Article
Journal
British Journal of Pharmacology
Publisher
Wiley (Blackwell Publishing)
Publication Date
Oct 01, 2009
Volume
158
Issue
4
Pages
1165–1172
Identifiers
DOI: 10.1111/j.1476-5381.2009.00384.x
PMID: 19785651
Source
Medline
License
Unknown

Abstract

The epitopes 9-14 and 17-21 are the temperature-sensitive regions within Abeta40. The betaSBPs, Abeta16-23 and 17-24 reversed temperature-induced beta-sheet formation, and decreased Abeta40 aggregation. The results suggest that the 17-23 epitope of Abeta40 is crucially involved in preventing Abeta40 aggregation and consequent deposition of Abeta40 in AD brain.

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