Reversal of multidrug resistance by non-antitumor anthracycline analogs.
- Published Article
- Publication Date
Dec 01, 1984
It was found that three synthetic anthracycline analogs lacking not only antitumor activity but also calcium-antagonizing action possessed an activity to potentiate vincristine cytotoxicity against vincristine-resistant P388 leukemia. ID-8279, one of these analogs, significantly reversed resistance to vincristine and daunorubicin by increasing their intracellular accumulation.
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The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/6597118