Reversal of multidrug resistance by non-antitumor anthracycline analogs.

M Inaba; K Nagashima; Y Sakurai; M Fukui; Y Yanagi

Reversal of multidrug resistance by non-antitumor anthracycline analogs.

Authors

Inaba, M
Nagashima, K
Sakurai, Y
Fukui, M
Yanagi, Y

Type

Published Article

Journal

Gan

Publication Date

Dec 01, 1984

Volume

75

Issue

12

Pages

1049–1052

Identifiers

PMID: 6597118

Source

Medline

License

Unknown

Abstract

It was found that three synthetic anthracycline analogs lacking not only antitumor activity but also calcium-antagonizing action possessed an activity to potentiate vincristine cytotoxicity against vincristine-resistant P388 leukemia. ID-8279, one of these analogs, significantly reversed resistance to vincristine and daunorubicin by increasing their intracellular accumulation.

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. This record was last updated on 07/01/2016 and may not reflect the most current and accurate biomedical/scientific data available from NLM. The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/6597118

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