Reversal of multidrug resistance by non-antitumor anthracycline analogs.
- Authors
- Type
- Published Article
- Journal
- Gan
- Publication Date
- Dec 01, 1984
- Volume
- 75
- Issue
- 12
- Pages
- 1049–1052
- Identifiers
- PMID: 6597118
- Source
- Medline
- License
- Unknown
Abstract
It was found that three synthetic anthracycline analogs lacking not only antitumor activity but also calcium-antagonizing action possessed an activity to potentiate vincristine cytotoxicity against vincristine-resistant P388 leukemia. ID-8279, one of these analogs, significantly reversed resistance to vincristine and daunorubicin by increasing their intracellular accumulation.