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Reversal of multidrug resistance by non-antitumor anthracycline analogs.

Authors
  • Inaba, M
  • Nagashima, K
  • Sakurai, Y
  • Fukui, M
  • Yanagi, Y
Type
Published Article
Journal
Gan
Publication Date
Dec 01, 1984
Volume
75
Issue
12
Pages
1049–1052
Identifiers
PMID: 6597118
Source
Medline
License
Unknown

Abstract

It was found that three synthetic anthracycline analogs lacking not only antitumor activity but also calcium-antagonizing action possessed an activity to potentiate vincristine cytotoxicity against vincristine-resistant P388 leukemia. ID-8279, one of these analogs, significantly reversed resistance to vincristine and daunorubicin by increasing their intracellular accumulation.

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