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Reversal of the Kynurenine pathway of tryptophan catabolism may improve depression in ART-treated HIV-infected Ugandans.

Authors
  • Martinez, Priscilla
  • Tsai, Alexander C
  • Muzoora, Conrad
  • Kembabazi, Annet
  • Weiser, Sheri D
  • Huang, Yong
  • Haberer, Jessica E
  • Martin, Jeffrey N
  • Bangsberg, David R
  • Hunt, Peter W
Type
Published Article
Journal
JAIDS Journal of Acquired Immune Deficiency Syndromes
Publisher
Ovid Technologies (Wolters Kluwer) - Lippincott Williams & Wilkins
Publication Date
Apr 01, 2014
Volume
65
Issue
4
Pages
456–462
Identifiers
DOI: 10.1097/QAI.0000000000000062
PMID: 24220289
Source
Medline
License
Unknown

Abstract

Indoleamine 2,3-dioxygenase-1-mediated tryptophan catabolism may contribute to depression symptom severity among HIV-infected individuals, particularly among those with poor dietary protein intake. ART-mediated improvements in depressive symptom severity may also be at least partially mediated by immunologic mechanisms. Interventions to reduce immune activation, and dietary protein supplementation, may be promising strategies to further reduce depression in this setting.

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