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Return of fertility after discontinuation of the once-a-month injectable contraceptive Cyclofem.

Authors
  • Bahamondes, L
  • Lavín, P
  • Ojeda, G
  • Petta, C
  • Diaz, J
  • Maradiegue, E
  • Monteiro, I
Type
Published Article
Journal
Contraception
Publisher
Elsevier
Publication Date
May 01, 1997
Volume
55
Issue
5
Pages
307–310
Identifiers
PMID: 9220228
Source
Medline
Keywords
License
Unknown

Abstract

Cyclofem, a monthly injectable contraceptive containing 5 mg estradiol cypionate and 25 mg medroxyprogesterone acetate, has been registered in several Latin American countries; however, the return to fertility after method discontinuation has not been investigated. To address this issue, 70 women were followed who had participated in introductory studies in Brazil, Chile, Colombia, and Peru during 1992-94 and who then discontinued injectable use to achieve pregnancy. The mean number of Cyclofem injections was 7.1 (range, 1-19). The fertility rate was 1.4 at the end of the first month after Cyclofem discontinuation, 52.9 after 6 months, and 82.9 at 12 months. 55 pregnancies (94.8%) ended in live-term births, with no congenital malformations; there were 2 spontaneous abortions in the first trimester. The number of months required to become pregnant was not significantly associated with maternal age, body weight, number of injections, or country site. The return to fertility for this method is comparable to that following discontinuation of copper IUDs, barrier methods, and oral contraceptives. Since information on return to fertility is essential to informed choice, these findings should be incorporated into educational and counseling materials for providers and potential acceptors of this new contraceptive method.

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