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Retrospective accuracy analysis of MRI based lesion size measurement in neuroblastic tumors: which sequence should we choose?

Authors
  • Gassenmaier, Sebastian1
  • Tsiflikas, Ilias1
  • Maennlin, Simon1
  • Urla, Cristian2
  • Warmann, Steven W.2
  • Schaefer, Juergen F.1
  • 1 University Hospital Tuebingen, Hoppe-Seyler-Straße 3, Tuebingen, 72076, Germany , Tuebingen (Germany)
  • 2 University Children’s Hospital Tuebingen, Tuebingen, Germany , Tuebingen (Germany)
Type
Published Article
Journal
BMC Medical Imaging
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Sep 10, 2020
Volume
20
Issue
1
Identifiers
DOI: 10.1186/s12880-020-00503-1
Source
Springer Nature
Keywords
License
Green

Abstract

BackgroundMR imaging of neuroblastic tumors is widely used for assessing the effect of chemotherapy on tumor size. However, there are some concerns that MRI might falsely estimate lesion diameters due to calcification and fibrosis. Therefore, the aim of our study was to compare neuroblastic tumor size based on MRI measurements to histopathology measurements of the resected specimens as standard of reference.MethodsInclusion criteria were diagnosis of a neuroblastic tumor, MR imaging within 100 days to surgery and gross total resection without fragmentation of the tumor between 2008 and 2019. Lesion diameters were measured by two radiologists according to RECIST 1.1 in axial plane in T2w turbo spin echo (TSE), diffusion-weighted imaging (DWI), and in T1w pre- and postcontrast sequences. Furthermore, the largest lesion size in three-dimensions was noted. The largest diameter of histopathology measurements of each specimen was used for comparison with MRI.ResultsThirty-seven patients (mean age: 5 ± 4 years) with 38 lesions (neuroblastoma: n = 17; ganglioneuroblastoma: n = 11; ganglioneuroma: n = 10) were included in this retrospective study. There was excellent intra-class correlation coefficient between both readers for all sequences (> 0.9) Tumor dimensions of reader 1 based on axial MRI measurements were significantly smaller with the following median differences (cm): T1w precontrast − 1.4 (interquartile range (IQR): 1.8), T1w postcontrast − 1.0 (IQR: 1.9), T2w TSE: -1.0 (IQR: 1.6), and DWI -1.3 (IQR: 2.2) (p < 0.001 for all sequences). However, the evaluation revealed no significant differences between the three-dimensional measurements and histopathology measurements of the resected specimens regardless of the applied MRI sequence.ConclusionsAxial MRI based lesion size measurements are significantly smaller than histopathological measurements. However, there was no significant difference between three-dimensional measurements and histopathology measurements of the resected specimens. T2w TSE and T1w postcontrast images provided the lowest deviation and might consequently be preferred for measurements.

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