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Retrograde reactions of Clarke's nucleus neurons after human spinal cord injury.

Authors
  • 1
Type
Published Article
Journal
Annals of Neurology
0364-5134
Publisher
Wiley Blackwell (John Wiley & Sons)
Publication Date
Volume
54
Issue
4
Pages
534–539
Identifiers
PMID: 14520670
Source
Medline

Abstract

Successful axon regeneration depends on the expression of regeneration-associated genes by axotomized neurons. Here, we demonstrate, for the first time to our knowledge, the expression of regeneration-associated genes by axotomized human CNS neurons. In situ hybridization and immunohistochemistry showed a transient induction of GAP-43 and c-jun in Clarke's nucleus neurons caudal to traumatic human spinal cord injury. These results support experimental data that nonregenerating central nervous system neurons can temporarily upregulate regeneration-associated genes, reflecting a transient regenerative capacity that fails over time.

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