Affordable Access

Retrograde reactions of Clarke's nucleus neurons after human spinal cord injury.

Authors
  • Schmitt, Andreas B1
  • Breuer, Sebastian
  • Polat, Leyla
  • Pech, Katrin
  • Kakulas, Byran
  • Love, Seth
  • Martin, Didier
  • Schoenen, Jean
  • Noth, Johannes
  • Brook, Gary A
  • 1 Aachen Spinal Cord Research Center, Department of Neurology, University Hospital Aachen, Aachen, Germany. [email protected]
Type
Published Article
Journal
Annals of neurology
Publication Date
October 2003
Volume
54
Issue
4
Pages
534–539
Identifiers
PMID: 14520670
Source
Medline
License
Unknown

Abstract

Successful axon regeneration depends on the expression of regeneration-associated genes by axotomized neurons. Here, we demonstrate, for the first time to our knowledge, the expression of regeneration-associated genes by axotomized human CNS neurons. In situ hybridization and immunohistochemistry showed a transient induction of GAP-43 and c-jun in Clarke's nucleus neurons caudal to traumatic human spinal cord injury. These results support experimental data that nonregenerating central nervous system neurons can temporarily upregulate regeneration-associated genes, reflecting a transient regenerative capacity that fails over time.

Report this publication

Statistics

Seen <100 times