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Retinoic acid signaling is critical during the totipotency window in early mammalian development

Authors
  • Iturbide, Ane1
  • Ruiz Tejeda Segura, Mayra L.1, 2, 3
  • Noll, Camille1
  • Schorpp, Kenji4
  • Rothenaigner, Ina4
  • Ruiz-Morales, Elias R.1, 5
  • Lubatti, Gabriele1, 2, 3
  • Agami, Ahmed1
  • Hadian, Kamyar4
  • Scialdone, Antonio1, 2, 3
  • Torres-Padilla, Maria-Elena1, 6
  • 1 Institute of Epigenetics and Stem Cells (IES), Helmholtz Zentrum München, Munich, Germany , Munich (Germany)
  • 2 Institute of Functional Epigenetics (IFE), Helmholtz Zentrum München, Neuherberg, Germany , Neuherberg (Germany)
  • 3 Institute of Computational Biology (ICB), Helmholtz Zentrum München, Neuherberg, Germany , Neuherberg (Germany)
  • 4 Assay Development & Screening Platform, Institute of Molecular Toxicology & Pharmacology (TOXI), Helmholtz Zentrum München, Neuherberg, Germany , Neuherberg (Germany)
  • 5 Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK , Cambridge (United Kingdom)
  • 6 Faculty of Biology, Ludwig-Maximilians Universität, Munich, Germany , Munich (Germany)
Type
Published Article
Journal
Nature Structural & Molecular Biology
Publisher
Springer Nature
Publication Date
May 27, 2021
Volume
28
Issue
6
Pages
521–532
Identifiers
DOI: 10.1038/s41594-021-00590-w
Source
Springer Nature
Disciplines
  • resource
License
Green

Abstract

High-throughput chemical screening identifies retinoic acid signaling as a regulatory pathway of 2-cell-like cell reprogramming and early mouse development.

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