The present study aims to examine the relationship between urban vitality, healthy environment and density through the city of Istanbul, which is going through the Covid-19 outbreak. In this context, an online survey was conducted to measure the assessments of the residents living in districts with different density categories regarding the neighborhoods and the city they live in. The evaluations made by the citizens in the dimensions of vitality, mobility, safety, healthiness, cleanliness, orderliness were reduced to two main factors as “urban vitality” and “healthy environment” using Principal Components Analysis. Then, the evaluations regarding these six variables and two factors were subjected to cross-inquiries with the personal, residential and district characteristics. Urban residents were also asked to evaluate the city life before and after the Covid-19 outbreak. The main findings of the study reveal that there is a statistically significant difference between the density levels of the districts in terms of the perception of urban vitality and some sub-variables of healthy environment. Also, there is an observed change in the thoughts about urban life in Istanbul due to the outbreak.