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Retention of Human-Induced Pluripotent Stem Cells (hiPS) With Injectable HA Hydrogels for Vocal Fold Engineering.

Authors
  • Imaizumi, Mitsuyoshi1
  • Li-Jessen, Nicole Y K2
  • Sato, Yuka1
  • Yang, David T3
  • Thibeault, Susan L4
  • 1 1 Department of Otolaryngology, School of Medicine, Fukushima Medical University, Fukushima City, Japan. , (Japan)
  • 2 2 School of Communication Sciences and Disorders, McGill University, Montreal, QC, Canada. , (Canada)
  • 3 3 Department of Pathology, University of Wisconsin-Madison, Madison, Wisconsin, USA.
  • 4 4 Division of Otolaryngology-Head and Neck Surgery, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Type
Published Article
Journal
Annals of Otology Rhinology & Laryngology
Publisher
SAGE Publications
Publication Date
Apr 01, 2017
Volume
126
Issue
4
Pages
304–314
Identifiers
DOI: 10.1177/0003489417691296
PMID: 28290232
Source
Medline
Keywords
License
Unknown

Abstract

Human-iPS survived in injured rat vocal folds. The HA hydrogel with hiPS and EGF ameliorated the fibrotic response. Additional work is necessary to optimize hiPS differentiation and further confirm the safety of hiPS for clinical applications.

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