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ret/PTC-1 expression alters the immunoprofile of thyroid follicular cells.

Journal
Molecular Cancer
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Jan 01, 2008
Volume
7
Issue
1
Identifiers
DOI: 10.1186/1476-4598-7-44
Keywords
Disciplines
  • Medicine
License
Unknown

Abstract

Hashimoto Thyroiditis (H.T.) is a destructive autoimmune thyroid condition whose precise molecular pathogenesis remains unclear. ret/PTC-1 is a chimeric transcript which has been described in autoimmune thyroid disease (AITD) and thyroid neoplasia. The purpose of this study was to observe the immunogenic effect exposure to H.T. and control lymphocyte supernatant would have on normal (Nthy-ori) and ret/PTC-1 (TPC-1) expressing thyroid cell line models.

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