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RET and GDNF mutations are rare in fetuses with renal agenesis or other severe kidney development defects.

Authors
  • 1
Type
Published Article
Journal
Journal of Medical Genetics
1468-6244
Publisher
BMJ
Publication Date
Volume
48
Issue
7
Pages
497–504
Identifiers
DOI: 10.1136/jmg.2010.088526
PMID: 21490379
Source
Medline
License
Unknown

Abstract

These results suggest that genomic alteration of RET or GDNF is not a major mechanism leading to renal agenesis and other severe kidney development defects. Analysis of a larger series of patients will be necessary to validate the association of the RET intron 1 variant rs2506012 with renal development defects.

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