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Resveratrol reserved hypoxia-ischemia induced childhood hippocampal dysfunction and neurogenesis via improving mitochondrial dynamics.

Authors
  • Li, Hong1
  • Li, Xiao2
  • Liu, Zhizhen2
  • Wu, Shirun1
  • Guo, Jinwei1
  • Shi, Ruiling1
  • Sun, Yuqing2
  • Wang, Yufei2
  • Yin, Huaiqing3
  • 1 Department of Pediatrics, The First Hospital of Shanxi Medical University, China. , (China)
  • 2 Department of Biochemistry and Molecular Biology, Shanxi Medical University, China. , (China)
  • 3 Department of Pediatrics, The First Hospital of Shanxi Medical University, China. Electronic address: [email protected] , (China)
Type
Published Article
Journal
Neuroscience research
Publication Date
Dec 01, 2020
Volume
161
Pages
51–58
Identifiers
DOI: 10.1016/j.neures.2019.11.012
PMID: 31790723
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Early life stress usually causes the abnormal brain development and results in the onset of cognitive and emotional disorders in later childhood. Neonatal hypoxic ischemia (HI) causes dramatic brain damage in early life and resulted in serious impairment to brain development. Hippocampal neurogenesis, as one of the key structural plasticity to mediate animal behaviors, can be impact by neonatal HI until child stage. In our study, we identified the natural product resveratrol (RES) as the potential alternative therapy to improve brain functions of childhood mice after underwent neonatal HI. Treatment of RES improved the spatial learning and memory in morris water maze and increased the recognize ability in objective recognition task. Moreover, RES also attenuate the depressive and anxiety like mood in child mice after experiencing neonatal HI. Brain morphological study showed RES promote the proliferation of neural stem cells and increase the neuronal differentiation in hippocampal dentate gyrus (DG) region. Our in vitro study in C17.2 neural stem cell line demonstrated RES could prevent the mitochondrial fragmentation induced by hypoxia. Moreover, same effect was also observed in primary cultural neurons. To summarize, RES could prevent the cognitive deficit and depressive/anxiety mood in childhood with experience of neonatal HI via promoting hippocampal neurogenesis. Improving mitochondrial dynamics could be one of the key biological mechanisms underlying such effects of RES. Copyright © 2019 Elsevier B.V. and Japan Neuroscience Society. All rights reserved.

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