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Resveratrol Preserves Cerebrovascular Density and Cognitive Function in Aging Mice

Authors
  • Oomen, Charlotte A.1
  • Farkas, Eszter2
  • Roman, Viktor1
  • van der Beek, Eline M.3
  • Luiten, Paul G. M.1
  • Meerlo, Peter1
  • 1 Department of Molecular Neurobiology, Center for Behavior and Neuroscience, University of Groningen, Groningen, The Netherlands
  • 2 Department of Physiology, School of Medicine, University of Szeged, Szeged, Hungary
  • 3 Danone Research, Centre for Specialised Nutrition, Wageningen, The Netherlands
Type
Published Article
Journal
Frontiers in Aging Neuroscience
Publisher
Frontiers Media SA
Publication Date
Dec 09, 2009
Volume
1
Identifiers
DOI: 10.3389/neuro.24.004.2009
Source
Frontiers
Keywords
Disciplines
  • Neuroscience
  • Original Research
License
Green

Abstract

Resveratrol, a natural polyphenol abundant in grapes and red wine, has been reported to exert numerous beneficial health effects. Among others, acute neuroprotective effects of resveratrol have been described in several models of neurodegeneration, both in vitro and in vivo. In the present study we examined the neuroprotective effects of long-term dietary supplementation with resveratrol in mice on behavioral, neurochemical and cerebrovascular level. We report a preserved cognitive function in resveratrol-treated aging mice, as shown by an enhanced acquisition of a spatial Y-maze task. This was paralleled by a higher microvascular density and a lower number of microvascular abnormalities in comparison to aging non-treated control animals. We found no effects of resveratrol supplementation on cholinergic cell number or fiber density. The present findings support the hypothesis that resveratrol exerts beneficial effects on the brain by maintaining cerebrovascular health. Via this mechanism resveratrol can contribute to the preservation of cognitive function during aging.

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