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Resveratrol Enhances Exercise-Induced Cellular and Functional Adaptations of Skeletal Muscle in Older Men and Women.

Authors
  • Alway, Stephen E1, 2, 3
  • McCrory, Jean L1, 2
  • Kearcher, Kalen1, 2
  • Vickers, Austen1, 2
  • Frear, Benjamin1, 2
  • Gilleland, Diana L1
  • Bonner, Daniel E1
  • Thomas, James M1
  • Donley, David A1
  • Lively, Mathew W1, 4
  • Mohamed, Junaith S1, 3
  • 1 Division of Exercise Physiology, Department of Human Performance and Applied Exercise Science, West Virginia University School of Medicine, Morgantown.
  • 2 West Virginia Clinical and Translational Science Institute, Morgantown.
  • 3 Center for Neuroscience, Morgantown, West Virginia.
  • 4 Section of Rheumatology, Department of Medicine, West Virginia University School of Medicine, Morgantown.
Type
Published Article
Journal
The journals of gerontology. Series A, Biological sciences and medical sciences
Publication Date
Nov 09, 2017
Volume
72
Issue
12
Pages
1595–1606
Identifiers
DOI: 10.1093/gerona/glx089
PMID: 28505227
Source
Medline
Keywords
License
Unknown

Abstract

Older men (n = 12) and women (n = 18) 65-80 years of age completed 12 weeks of exercise and took either a placebo or resveratrol (RSV) (500 mg/d) to test the hypothesis that RSV treatment combined with exercise would increase mitochondrial density, muscle fatigue resistance, and cardiovascular function more than exercise alone. Contrary to our hypothesis, aerobic and resistance exercise coupled with RSV treatment did not reduce cardiovascular risk further than exercise alone. However, exercise added to RSV treatment improved the indices of mitochondrial density, and muscle fatigue resistance more than placebo and exercise treatments. In addition, subjects that were treated with RSV had an increase in knee extensor muscle peak torque (8%), average peak torque (14%), and power (14%) after training, whereas exercise did not increase these parameters in the placebo-treated older subjects. Furthermore, exercise combined with RSV significantly improved mean fiber area and total myonuclei by 45.3% and 20%, respectively, in muscle fibers from the vastus lateralis of older subjects. Together, these data indicate a novel anabolic role of RSV in exercise-induced adaptations of older persons and this suggests that RSV combined with exercise might provide a better approach for reversing sarcopenia than exercise alone.

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