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Resuscitation-promoting factors (Rpf): in search of inhibitors.

Authors
  • Kaprelyants, Arseny S
  • Mukamolova, Galina V
  • Ruggiero, Alessia
  • Makarov, Vadim A
  • Demina, Galina R
  • Shleeva, Margarita O
  • Potapov, Vasilii D
  • Shramko, Pavel A
Type
Published Article
Journal
Protein and Peptide Letters
Publisher
Bentham Science
Publication Date
Oct 01, 2012
Volume
19
Issue
10
Pages
1026–1034
Identifiers
PMID: 22533619
Source
Medline
License
Unknown

Abstract

Resuscitation promoting factors (Rpf) are a family of proteins secreted by actively growing actinobacteria, including Mycobacterium tuberculosis. Experimental evidence suggests that Rpfs play a distinct role in bacterial resuscitation and re-growth as well as reactivation of chronic tuberculosis in mice. The striking similarity of the Rpfs structure to cell wall hydrolysing enzymes has provided a basis for the development of novel low molecular weight inhibitors of Rpfs activity. In particular, recently characterised nitrophenylthiocyanate compounds could be considered as a promising scaffold for generation of therapeutic agents targeting reactivation of latent tuberculosis. This review describes recent progress in understanding of molecular mechanisms of Rpf biological activity.

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