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Results of low-dose computed tomography as a regular health examination among Chinese hospital employees.

Authors
  • Zhang, Yang1
  • Jheon, Sanghoon2
  • Li, Huimin3
  • Zhang, Huibiao4
  • Xie, Yaozeng5
  • Qian, Bin6
  • Lin, Kaihong7
  • Wang, Shengping8
  • Fu, Chen9
  • Hu, Hong10
  • Zheng, Ying11
  • Li, Yuan12
  • Chen, Haiquan13
  • 1 Department of Thoracic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China. , (China)
  • 2 Department of Thoracic and Cardiovascular Surgery, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seoul, Korea. , (North Korea)
  • 3 Department of Radiology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China. , (China)
  • 4 Department of Thoracic Surgery, Huadong Hospital Fudan University, Shanghai, China. , (China)
  • 5 Medical Imaging Division, Liaocheng Second People's Hospital, Linqing, Liaocheng, Shandong Province, China. , (China)
  • 6 Department of Thoracic Surgery, Jiang du People's Hospital of Yangzhou City, Yangzhou, China. , (China)
  • 7 Department of Surgical Oncology, People's Hospital of Jieyang Industrial Transfer Park, Guangdong, China. , (China)
  • 8 Department of Radiology, Fudan University Shanghai Cancer Center, Shanghai, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China. , (China)
  • 9 Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China. , (China)
  • 10 Department of Thoracic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China. Electronic address: [email protected] , (China)
  • 11 Department of Cancer Prevention, Fudan University Shanghai Cancer Center, Shanghai, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China. , (China)
  • 12 Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China. Electronic address: [email protected]om. , (China)
  • 13 Department of Thoracic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China; Institute of Biomedical Sciences, Fudan University, Shanghai, China; State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, China. Electronic address: [email protected] , (China)
Type
Published Article
Journal
The Journal of thoracic and cardiovascular surgery
Publication Date
Sep 01, 2020
Volume
160
Issue
3
Identifiers
DOI: 10.1016/j.jtcvs.2019.10.145
PMID: 31987625
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Lung cancer is traditionally more prevalent in the elderly patients, men, and smokers. However, as low-dose computed tomography (LDCT) is increasingly popular, we hypothesized the disease spectrum might change. LDCT was performed as a part of regular health examinations in 8392 of 15,686 employees from 6 hospitals in different regions of China in 2012 to 2018. Clinicopathologic characteristics, including age, sex, smoking status, radiologic features, tumor histology, and pathologic stage, were retrospectively analyzed. LDCT incidentally detected lung cancer (pathologically confirmed) in a total of 179 (2.1%) hospital employees. The lung cancer detection rate was significantly greater in female than male (2.5% vs 1.3%, P = .001) patients. There was also a greater detection rate among nonsmokers than smokers, although statistical significance was not reached (2.2% vs 1.4%, P = .092). The lung cancer detection rate was 1.0% in the "age ≤40 years" group, 2.6% in the "40 < age ≤55 years" group, and 2.9% in the "age >55 years" group (P < .001). Among the hospital employees with lung cancer, 171 (95.5%) presented as ground-glass opacity, 177 (98.9%) were lung adenocarcinoma, 170 (95.0%) were early stage 0/IA, and 177 (98.9%) received curative surgical resection as the initial treatment. After a median follow-up of 38 months, no disease recurrence or death was observed among these patients. LDCT detected lung cancer in a significant proportion of young, female, and nonsmoking employees. The vast majority of these lung cancers were early stage, with extremely good prognosis. Copyright © 2019 The American Association for Thoracic Surgery. Published by Elsevier Inc. All rights reserved.

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