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Results of the administration of bisphosphonates for the prevention of periosteal bone formation following Moloney sarcoma virus-induced tumors.

Authors
Type
Published Article
Journal
Folia biologica
Publication Date
Volume
39
Issue
6
Pages
297–303
Identifiers
PMID: 7926159
Source
Medline
License
Unknown

Abstract

The effect of continuous and discontinuous administration of bisphosphonates on the periosteal osteogenesis induced by Moloney sarcoma development was studied in mice by histological examination and bone dry mass evaluation. Both EHDP and Cl2MDP did not inhibit periosteal osteogenesis but EHDP, in contrast to Cl2MDP, inhibited the mineralization of osteoid. This inhibition was completely reversible after the withdrawal of the drug. Within two weeks the remineralization of newly formed bone matrix was completed.

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