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Restriction fragment length polymorphism caused by a deletion within the human c-abl gene (ABL).

Authors
  • Xu, D Q
  • Galibert, F
Type
Published Article
Journal
Proceedings of the National Academy of Sciences
Publisher
Proceedings of the National Academy of Sciences
Publication Date
May 01, 1986
Volume
83
Issue
10
Pages
3447–3450
Identifiers
PMID: 3010299
Source
Medline
License
Unknown

Abstract

A restriction fragment length polymorphism at the human c-abl locus (ABL) has been detected in 67 unrelated individuals by agarose gel electrophoresis and Southern blot hybridization using 32P-labeled v-abl probes. This polymorphism is generated by the existence of two alleles, a and b, which are in Hardy-Weinberg equilibrium, with frequencies of 94.8% and 5.2%, respectively. The minor allele, b, is due to a deletion of about 500 base pairs in an intron located downstream of the codon for the phosphate-acceptor tyrosine residue of the c-abl gene product.

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