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Resting-state functional hypoconnectivity of amygdala in clinical high risk state and first-episode schizophrenia.

Authors
  • 1 Department of Psychiatry, The Second Xiangya Hospital, Central South University, No. 139, Middle Renmin Road, Changsha, 410011, China. , (China)
  • 2 Mental Health Institute of the Second Xiangya Hospital, Central South University, Changsha, Hunan, China. , (China)
  • 3 National Clinical Research Center on Mental Disorders, Changsha, Hunan, China. , (China)
  • 4 National Technology Institute on Mental Disorders, Changsha, Hunan, China. , (China)
  • 5 Hunan Key Laboratory of Psychiatry and Mental Health, Changsha, Hunan, China. , (China)
  • 6 Department of Psychiatry, The Second Xiangya Hospital, Central South University, No. 139, Middle Renmin Road, Changsha, 410011, China. [email protected] , (China)
  • 7 Mental Health Institute of the Second Xiangya Hospital, Central South University, Changsha, Hunan, China. [email protected] , (China)
  • 8 National Clinical Research Center on Mental Disorders, Changsha, Hunan, China. [email protected] , (China)
  • 9 National Technology Institute on Mental Disorders, Changsha, Hunan, China. [email protected] , (China)
  • 10 Hunan Key Laboratory of Psychiatry and Mental Health, Changsha, Hunan, China. [email protected] , (China)
  • 11 Department of Psychiatry, The Second Xiangya Hospital, Central South University, No. 139, Middle Renmin Road, Changsha, 410011, China. [email protected] , (China)
  • 12 Mental Health Institute of the Second Xiangya Hospital, Central South University, Changsha, Hunan, China. [email protected] , (China)
  • 13 National Clinical Research Center on Mental Disorders, Changsha, Hunan, China. [email protected] , (China)
  • 14 National Technology Institute on Mental Disorders, Changsha, Hunan, China. [email protected] , (China)
  • 15 Hunan Key Laboratory of Psychiatry and Mental Health, Changsha, Hunan, China. [email protected] , (China)
Type
Published Article
Journal
Brain Imaging and Behavior
Publisher
Springer-Verlag
Publication Date
Oct 01, 2020
Volume
14
Issue
5
Pages
1840–1849
Identifiers
DOI: 10.1007/s11682-019-00124-5
PMID: 31134583
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Resting-state functional hypoconnectivity of the amygdala with several brain regions has been identified in patients with schizophrenia. However, little is known about it in individuals at clinical high risk state. Treatment-seeking, drug-naive young adults were recruited for the study. The participants included 33 adults at Clinical High Risk (CHRs), 31 adults with first-episode schizophrenia (FSZs), and 37 age-, gender-, and education-matched healthy controls. All the participants were subjected to resting-state functional magnetic resonance imaging scans. Seed-based voxel-wise amygdala/whole-brain functional connectivity (FC) was calculated and compared. In the CHR group, the right amygdala showed decreased FC with clusters located in the left orbital, right temporal, insular, and bilateral frontal and cingulate areas. In the FSZ group, the right amygdala showed decreased FC with clusters located in the right temporal, insular, cingulate, and frontal areas. Exactly 30% of the voxels showing decreased FC in the FSZ group coincided with those in the CHR group. No difference in FC was identified between the CHR and FSZ groups. Voxel-wise FC values with the left or right amygdala in the bilateral occipital cortex were negatively correlated with the PANSS total score in the FSZ group. Resting-state functional hypoconnectivity of the amygdala is a valuable risk phenotype of schizophrenia, and its distribution, rather than degree, distinguishes CHR state from schizophrenia. This particular hypoconnectivity in CHRs and FSZs is relatively independent of the symptomatology and may reflect a dysfunctional dopamine system.

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